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Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1

✍ Scribed by Joanne Ho; Chantal de Guise; Christie Kim; Serge Lemay; Xiao-Fan Wang; Jean-Jacques Lebrun


Book ID
118428410
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
535 KB
Volume
16
Category
Article
ISSN
0898-6568

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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an