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Forced expression of the cyclin-dependent kinase inhibitor p16INK4A in leukemic U-937 cells reveals dissociation between cell cycle and differentiation

✍ Scribed by Gösta Bergh; Anna Telleus; Anna Fritzon; Sten Kornfält; Ellinor Johnson; Inge Olsson; Urban Gullberg


Book ID
114216733
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
418 KB
Volume
29
Category
Article
ISSN
0301-472X

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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an