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Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer

✍ Scribed by Tamotsu Inoue; Kenji Hibi; Goro Nakayama; Yoshinao Komatsu; Tomoki Fukuoka; Yasuhiro Kodera; Katsuki Ito; Seiji Akiyama; Akimasa Nakao

Book ID: 106179649
Publisher: Springer Japan
Year: 2005
Tongue: English
Weight: 185 KB
Volume: 40
Category: Article
ISSN: 0944-1174
DOI: 10.1007/s00535-004-1512-9

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has