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Transcription factor-binding sites in the thymidylate synthase gene: predictors of outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin?

✍ Scribed by Paré, L; Marcuello, E; Altés, A; del Rio, E; Sedano, L; Barnadas, A; Baiget, M

Book ID
110075523
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
32 KB
Volume
9
Category
Article
ISSN
1470-269X

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30