## Background: The human mismatch repair (mmr) gene hmsh2 (human muts homolog-2) is a dna repair gene that has been reported to be mutated in 40% of hereditary nonpolyposis colon cancer (hnpcc) kindreds and a small percentage of sporadic tumors. hnpcc is a cancer predisposition syndrome with an inc
โฆ LIBER โฆ
Expression and regulation of the mismatch-repair-enzyme HMSH-2 in human skin tumors
โ Scribed by Reichrath, J.; Rass, K.; Gutwein, P.; Welter, C.; Seifert, M.; Zang, K.D.; Tilgen, W.
- Book ID
- 119562069
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 191 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0923-1811
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## Background: Several convincing studies have shown that the hmsh2 gene plays major roles in mismatch repair by recognizing mismatched bases and preventing mutations during dna replication. loss of this function may result in the accumulation of dna replication errors or even the mutator phenotype
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