𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone

✍ Scribed by Juha Grönlund; Teijo I. Saari; Nora M. Hagelberg; Pertti J. Neuvonen; Klaus T. Olkkola; Kari Laine


Book ID
108642503
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
909 KB
Volume
70
Category
Article
ISSN
0306-5251

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


A validated SIM GC/MS method for the sim
✍ Marios Spanakis; Ioannis S. Vizirianakis; Maria Mironidou-Tzouveleki; Ioannis Ni 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB 👁 2 views

## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i

Validation of higher-throughput high-per
✍ Inhou Chu; Leonard Favreau; Tony Soares; Chin-chung Lin; Amin A. Nomeir 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB 👁 2 views

In the early stage of drug discovery, thousands of new chemical entities (NCEs) may be screened before a single drug candidate can be identified for development. In order to accelerate the drug discovery process, we have developed higher-throughput enzyme assays to evaluate the inhibition of cytochr