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Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone

✍ Scribed by Oliver Kummer; Felix Hammann; Claudine Moser; Olivier Schaller; Jürgen Drewe; Stephan Krähenbühl

Publisher
Springer
Year
2010
Tongue
English
Weight
196 KB
Volume
67
Category
Article
ISSN
0031-6970

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Forecasting CYP2D6 and CYP3A4 Risk with
Forecasting CYP2D6 and CYP3A4 Risk with a Global/Local Fusion Model of CYP450 Inhibition
✍ Todd Ewing; Miklos Feher 📂 Article 📅 2010 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 748 KB

## Abstract This work presents a method to utilize the ever‐expanding corporate collections of CYP450 inhibition data to forecast the future risk of compounds not yet synthesized. The global/local fusion method differs from existing QSAR methods, in that each prediction is derived from a custom‐bui