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Probabilistic Prediction of the Human CYP3A4 and CYP2D6 Metabolism Sites

✍ Scribed by Justas Dapkunas; Andrius Sazonovas; Pranas Japertas


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
136 KB
Volume
6
Category
Article
ISSN
1612-1872

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In Vitro/in Vivo scaling of alprazolam m
✍ Noriko Hirota; Kiyomi Ito; Takafumi Iwatsubo; Carol E. Green; Charles A. Tyson; πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 243 KB πŸ‘ 1 views

We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a