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Constituents of Zingiber aromaticum and Their CYP3A4 and CYP2D6 Inhibitory Activity.

✍ Scribed by Subehan Subehan; Tepy Usia; Shigetoshi Kadota; Yasuhiro Tezuka


Publisher
John Wiley and Sons
Year
2005
Weight
9 KB
Volume
36
Category
Article
ISSN
0931-7597

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A validated SIM GC/MS method for the sim
✍ Marios Spanakis; Ioannis S. Vizirianakis; Maria Mironidou-Tzouveleki; Ioannis Ni πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 347 KB πŸ‘ 2 views

## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i