✦ LIBER ✦

Exploring the Role of Bromine at C(10) of (+)-4-[2-[4-(8-Chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11( R )-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): The Discovery of Indolocycloheptapyridine Inhibitors of Farnesyl Protein Transferase

✍ Scribed by Taveras, Arthur G.; Aki, Cynthia; Chao, Jianping; Doll, Ronald J.; Lalwani, Tarik; Girijavallabhan, Viyyoor; Strickland, Corey L.; Windsor, William T.; Weber, Patricia; Hollinger, Frank; Snow, Mark; Patton, Robert; Kirschmeier, Paul; James, Linda; Liu, Ming; Nomeir, Amin

Book ID: 127084642
Publisher: American Chemical Society
Year: 2002
Tongue: English
Weight: 281 KB
Volume: 45
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm010463v

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5 H -benzo[5,6]cyclohepta[1,2- b ]- pyridin-11( R )-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

✍ Njoroge, F. George; Taveras, Arthur G.; Kelly, Joseph; Remiszewski, Stacy; Malla 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 404 KB

Analogues of 1-(3,10-Dibromo-8-chloro-6,

Analogues of 1-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase

✍ Adriano Afonso; Jay Weinstein; Joseph Kelly; Ronald Wolin; Stuart B. Rosenblum; 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 253 KB

Inhibitors of Farnesyl Protein Transfera

Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5 H -benzo[5,6]- cyclohepta[1,2- b ]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5 H -benzo[5,6]cyclohepta[1,2- b ]pyridin-11-yl)piperazine 1

✍ Mallams, Alan K.; Rossman, Randall R.; Doll, Ronald J.; Girijavallabhan, Viyyoor 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 391 KB

Structure−Activity Relationship of 3-Sub

Structure−Activity Relationship of 3-Substituted N -(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11 H -benzo[5,6]cyclohepta[1,2- b ]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

✍ Njoroge, F. George; Vibulbhan, Bancha; Rane, Dinananth F.; Bishop, W. Robert; Pe 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 411 KB