The title compound, C 14 H 12 ClN, has a tricyclic fused-ring system composed of a benzene ring, a pyridine ring and a central nonplanar seven-membered ring.
Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5 H -benzo[5,6]- cyclohepta[1,2- b ]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5 H -benzo[5,6]cyclohepta[1,2- b ]pyridin-11-yl)piperazine 1
โ Scribed by Mallams, Alan K.; Rossman, Randall R.; Doll, Ronald J.; Girijavallabhan, Viyyoor M.; Ganguly, Ashit K.; Petrin, Joanne; Wang, Lynn; Patton, Robert; Bishop, W. Robert; Carr, Donna M.; Kirschmeier, Paul; Catino, Joseph J.; Bryant, Matthew S.; Chen, Kwang-Jong; Korfmacher, Walter A.; Nardo, Cymbelene; Wang, Shiyong; Nomeir, Amin A.; Lin, Chin-Chung; Li, Zujun; Chen, Jianping; Lee, Suining; Dell, Janet; Lipari, Philip; Malkowski, Michael; Yaremko, Bodan; King, Ivan; Liu, Ming
- Book ID
- 127376195
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 391 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
The carbanion derived from 8,1 l-dichloro-6,1 l-dihydro-5H-benzo [5,6]cyclohepta[l,2-bl pyridine (3) reacts with methyl acrylate to form the C. spirocyclopropane carboxylic acid methyl ester 6. Compound 6 was converted in five steps to the N-methyl 2'-ethylamino spirocyclopropane 2 (R=H) which was r