Analogues of 1-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase
β Scribed by Adriano Afonso; Jay Weinstein; Joseph Kelly; Ronald Wolin; Stuart B. Rosenblum; Michael Connolly; Timothy Guzi; Linda James; Donna Carr; Robert Patton; W.Robert Bishop; Paul Kirshmeier; M. Liu; L. Heimark; K.J. Chen; A.A. Nomeir
- Book ID
- 108480738
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 253 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0968-0896
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The carbanion derived from 8,1 l-dichloro-6,1 l-dihydro-5H-benzo [5,6]cyclohepta[l,2-bl pyridine (3) reacts with methyl acrylate to form the C. spirocyclopropane carboxylic acid methyl ester 6. Compound 6 was converted in five steps to the N-methyl 2'-ethylamino spirocyclopropane 2 (R=H) which was r