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Synthesis of a C11 spirocyclopropyl derivative of 8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2b]pyridine

✍ Scribed by Adriano Afonso; Mohindar S. Puar; Joseph Kelly; Andrew T. McPhail

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
190 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The carbanion derived from 8,1 l-dichloro-6,1 l-dihydro-5H-benzo [5,6]cyclohepta[l,2-bl pyridine (3) reacts with methyl acrylate to form the C. spirocyclopropane carboxylic acid methyl ester 6. Compound 6 was converted in five steps to the N-methyl 2'-ethylamino spirocyclopropane 2 (R=H) which was required for a structure-activity study based on the lead Farnesyl Protein Transferase inhibitor 1.

πŸ“œ SIMILAR VOLUMES

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The title compound, C 14 H 12 ClN, has a tricyclic fused-ring system composed of a benzene ring, a pyridine ring and a central nonplanar seven-membered ring.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v