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Excretion of tritiated 3–2′ dimethyl-4-diphenylamine

✍ Scribed by Paul Lo Gerfo; Frederic P. Herter

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
329 KB
Volume
4
Category
Article
ISSN
0022-4790

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✦ Synopsis

Tritiated 3-2'Dimcthyl4diphenylaminc was prepared by catalytic cxchangc and studics were carricd out in Wistar-Furth rats following subcutaneous injection. Blood levels reachcd their peak in 12 hours and this correlated closely with thc peak lcvels of label in thc urine and bile.

Ninety per cent of labelled compound was excreted within 5 days, less than 3% uf the tritium excreted was in thc form of tritiated water. Sixty-five per cent of cxcrctcd labcl appeared in the stools, and 35%) in the urine of intact animals. In animals with bile fistula, 85%) of the label appeared in the bile and 15% appeared in the urine. This data suggcstcd recirculation of the compound and radioautographs were done at 10 and 20 hours after injection of labelled carcinogen, to see if there was any preferred site of absorption in the G I . tract. None WJS found. Kadioautographs failcd to show any prcfcrrcd localization of thc labcl in the cells of the G.I. tract, liver, kidney, or bladder.

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