β Scribed by D. M. Dulik; W. H. Soine
No coin nor oath required. For personal study only.
The synthesis of 4,6β^2^H~2~β1,2,3βbenzenetriol from 1,2,3βbenzenetriol was possible under both acid and base catalyzed conditions. However, under simulated physiological conditions it was observed that the label underwent exchange and was lost. Using a three step synthesis, 5β^2^Hβ1,2,3βbenzenetriol was synthesized and the label was found to be stable to exchange under the same conditions. Using this synthesis, 5β^3^Hβ1,2, 3βbenzenetriol was synthesized with a specific activity of 7.6 mCi/mmole and of suitable purity for use in metabolic studies.
π SIMILAR VOLUMES
Thermolysis of 0.05 M aqueous 5-hydroxymethyl-2-furaldehyde (HMF) at 27.5 MPa and 290 to 400Β°C led to the formation of 1,2,4-benzenetriol in yields of up to 46% at 50% HMF conversion. The reaction temperature and water density have a significant effect on the product composition. Pseudofirst-order r
Tritiated 3-2'Dimcthyl4diphenylaminc was prepared by catalytic cxchangc and studics were carricd out in Wistar-Furth rats following subcutaneous injection. Blood levels reachcd their peak in 12 hours and this correlated closely with thc peak lcvels of label in thc urine and bile. Ninety per cent of
Tritiated N,N'-dibenzoyl-l,3-diaminopropan-2-ol, a compound mimicking a diacylglycerol moiety used as a lipid drug carrier was prepared from N,N'-dibenzoyl-l,3-diaminopropan-2-o1 by isotopic exchange in the presence of rhodium chloride. Preliminary preparation of the deuterated analog was made in o
A new apparatus was c o n s t r u c t e d t o t r i t i a t e b i o l o g i c a l molecules u s i n g mass analysed t r i t i u m i o n beams. magnetic s e c t o r o f t h i s d e v i c e was c o n s t r u c t e d o f h i g h f i e l d Sm-Co permanent magnets. Mass analyzed i o n s o f d e s i r e d