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Excitatory Amino Acid Receptor Ligands: Resolution, Absolute Stereochemistry, and Enantiopharmacology of 2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic Acid

✍ Scribed by Johansen, Tommy N.; Ebert, Bjarke; Bräuner-Osborne, Hans; Didriksen, Michael; Christensen, Inge T.; Søby, Karina K.; Madsen, Ulf; Krogsgaard-Larsen, Povl; Brehm, Lotte

Book ID
125985529
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
211 KB
Volume
41
Category
Article
ISSN
0022-2623

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We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com