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Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA

✍ Scribed by Tommy N. Johansen; Tine B. Stensbøl; Birgitte Nielsen; Stine B. Vogensen; Karla Frydenvang; Frank A. Sløk; Hans Brünum;uner-Osborne; Ulf Madsen; Povl Krogsgaard-Larsen


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
511 KB
Volume
13
Category
Article
ISSN
0899-0042

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Resolution, configurational assignment,
✍ Stine B. Vogensen; Henrik S. Jensen; Tine B. Stensbøl; Karla Frydenvang; Benny B 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 2 views

We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com

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✍ Eva H. Møller; Jan Egebjerg; Lotte Brehm; Tine B. Stensbøl; Tommy N. Johansen; U 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 702 KB

The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid (ATPO), is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA and GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propioni

AMPA receptor agonists: Resolution, conf
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We have previously shown that whereas (RS)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid (APPA) shows the characteristics of a partial agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, (S)-APPA is a full AMPA receptor agonist and (R)-APPA a weak