✦ LIBER ✦

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

✍ Scribed by Tommy N. Johansen; Yves L. Janin; Birgitte Nielsen; Karla Frydenvang; Hans Bräuner-Osborne; Tine B. Stensbøl; Stine B. Vogensen; Ulf Madsen; Povl Krogsgaard-Larsen

Book ID: 108479190
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 198 KB
Volume: 10
Category: Article
ISSN: 0968-0896
DOI: 10.1016/s0968-0896(02)00041-x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Excitatory Amino Acid Receptor Ligands:

Excitatory Amino Acid Receptor Ligands: Resolution, Absolute Stereochemistry, and Enantiopharmacology of 2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic Acid

✍ Johansen, Tommy N.; Ebert, Bjarke; Bräuner-Osborne, Hans; Didriksen, Michael; Ch 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 211 KB

Resolution, absolute stereochemistry, an

Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1–4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

✍ Eva H. Møller; Jan Egebjerg; Lotte Brehm; Tine B. Stensbøl; Tommy N. Johansen; U 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 702 KB

The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid (ATPO), is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA and GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propioni

Resolution, configurational assignment,

Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA

✍ Tommy N. Johansen; Tine B. Stensbøl; Birgitte Nielsen; Stine B. Vogensen; Karla 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 511 KB

Resolution, configurational assignment,

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist

✍ Stine B. Vogensen; Henrik S. Jensen; Tine B. Stensbøl; Karla Frydenvang; Benny B 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 2 views

We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com

Selective Agonists at Group II Metabotro

Selective Agonists at Group II Metabotropic Glutamate Receptors: Synthesis, Stereochemistry, and Molecular Pharmacology of ( S )- and ( R )-2-Amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric Acid

✍ Clausen, Rasmus P.; Bräuner-Osborne, Hans; Greenwood, Jeremy R.; Hermit, Mette B 📂 Article 📅 2002 🏛 American Chemical Society 🌐 English ⚖ 154 KB

Excitatory amino acid receptor antagonis

Excitatory amino acid receptor antagonists: Resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA)

✍ Tommy N. Johansen; Karla Frydenvang; Bjarke Ebert; Ulf Madsen; Povl Krogsgaard-L 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB 👁 2 views

We have previously shown that (RS)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA) is an antagonist at N-methyl-D-aspartic acid (NMDA) and (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors. We have now resolved ATAA via diastereomeric salt formation us