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Selective Agonists at Group II Metabotropic Glutamate Receptors: Synthesis, Stereochemistry, and Molecular Pharmacology of ( S )- and ( R )-2-Amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric Acid

✍ Scribed by Clausen, Rasmus P.; Bräuner-Osborne, Hans; Greenwood, Jeremy R.; Hermit, Mette B.; Stensbøl, Tine B.; Nielsen, Birgitte; Krogsgaard-Larsen, Povl


Book ID
120864813
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
154 KB
Volume
45
Category
Article
ISSN
0022-2623

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We have previously shown that whereas (RS)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid (APPA) shows the characteristics of a partial agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, (S)-APPA is a full AMPA receptor agonist and (R)-APPA a weak