✦ LIBER ✦

Resolution, Absolute Stereochemistry, and Pharmacology of the S-(+)- and R-(-)-Isomers of the Apparent Partial AMPA Receptor Agonist (R,S)-2-Amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic Acid [(R,S)-APPA]

✍ Scribed by Ebert, Bjarke; Lenz, Sibylle; Brehm, Lotte; Bregnedal, Peter; Hansen, Jan J.; Frederiksen, Kristen; Bogeso, Klaus P.; Krogsgaard-Larsen, Povl

Book ID: 127171340
Publisher: American Chemical Society
Year: 1994
Tongue: English
Weight: 858 KB
Volume: 37
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00033a003

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Molecular pharmacology of the AMPA agoni

Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA

✍ Ebert, Bjarke; Madsen, Ulf; Lund, Trine M.; Lenz, Sibylle M.; Krogsgaard-Larsen, 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 682 KB

AMPA receptor agonists: Resolution, conf

AMPA receptor agonists: Resolution, configurational assignment, and pharmacology of (+)-(S)- and (-)-(R)-2-amino-3-[3-hydroxy-5-(2-pyridyl)-isoxazol-4-yl]-propionic acid (2-Py-AMPA)

✍ Tommy N. Johansen; Bjarke Ebert; Erik Falch; Povl Krogsgaard-Larsen 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 2 views

We have previously shown that whereas (RS)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid (APPA) shows the characteristics of a partial agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, (S)-APPA is a full AMPA receptor agonist and (R)-APPA a weak

Excitatory amino acid receptor antagonis

Excitatory amino acid receptor antagonists: Resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA)

✍ Tommy N. Johansen; Karla Frydenvang; Bjarke Ebert; Ulf Madsen; Povl Krogsgaard-L 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB 👁 2 views

We have previously shown that (RS)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA) is an antagonist at N-methyl-D-aspartic acid (NMDA) and (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors. We have now resolved ATAA via diastereomeric salt formation us

Selective Agonists at Group II Metabotro

Selective Agonists at Group II Metabotropic Glutamate Receptors: Synthesis, Stereochemistry, and Molecular Pharmacology of ( S )- and ( R )-2-Amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric Acid

✍ Clausen, Rasmus P.; Bräuner-Osborne, Hans; Greenwood, Jeremy R.; Hermit, Mette B 📂 Article 📅 2002 🏛 American Chemical Society 🌐 English ⚖ 154 KB

ChemInform Abstract: Enantioselective Sy

ChemInform Abstract: Enantioselective Synthesis of (S)-2-Amino-3-(3-Hydroxy-5- methylisoxazol-4-yl)propanoic Acid (S)-AMPA.

✍ R. AMICI; P. PEVARELLO; M. COLOMBO; M. VARASI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Resolution, configurational assignment,

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist

✍ Stine B. Vogensen; Henrik S. Jensen; Tine B. Stensbøl; Karla Frydenvang; Benny B 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 2 views

We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com