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Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA

✍ Scribed by Ebert, Bjarke; Madsen, Ulf; Lund, Trine M.; Lenz, Sibylle M.; Krogsgaard-Larsen, Povl


Book ID
124104125
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
682 KB
Volume
24
Category
Article
ISSN
0197-0186

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AMPA receptor agonists: Resolution, conf
✍ Tommy N. Johansen; Bjarke Ebert; Erik Falch; Povl Krogsgaard-Larsen πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 173 KB πŸ‘ 2 views

We have previously shown that whereas (RS)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid (APPA) shows the characteristics of a partial agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, (S)-APPA is a full AMPA receptor agonist and (R)-APPA a weak