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ChemInform Abstract: Excitatory Amino-Acid Receptor Agonists. Synthesis and Pharmacology of Analogues of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid.

✍ Scribed by F. A. SLOEK; B. EBERT; Y. LANG; P. KROGSGAARD-LARSEN; S. M. LENZ; U. MADSEN

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199739149

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RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS follo

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