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Evidence that a hemoglobin adduct of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a 4-(3-pyridyl)-4-oxobutyl carboxylic acid ester

โœ Scribed by Carmella, Steven G.; Kagan, Shashi S.; Hecht, Stephen S.


Book ID
126334513
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
628 KB
Volume
5
Category
Article
ISSN
0893-228X

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Synthesis of 4- (methylnitrosamino)-1- (
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The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c