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Evidence for loss of heterozygosity in human psoriatic lesions

✍ Scribed by Zachos; Koumantaki; Vareltzidis; Spandidos

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 105 KB
Volume: 139
Category: Article
ISSN: 0007-0963
DOI: 10.1046/j.1365-2133.1998.02551.x

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✦ Synopsis

Psoriasis, a disease of human skin, is characterized by abnormal differentiation and hyperproliferation of keratinocytes; it has a genetic background. Using 11 highly polymorphic microsatellite markers on eight chromosome arms, we performed an allelotype analysis in 14 psoriatic plaques, in order to reveal any chromosome deletions involved in the development of the disease. We detected loss of heterozygosity (LOH) on at least one microsatellite marker in nine of 14 (64%) cases. We also observed particular genetic loci altered with LOH, on chromosomes 3p, 7p/q and 8p. Our results suggest that LOH is an important phenomenon in the development of psoriatic plaques, providing evidence for deletion of regulatory genes.

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