Evaluation of Sustained/Controlled-Release Dosage Forms of 3-Hydroxy-3-methylglutaryl–Coenzyme A (HMG-CoA) Reductase Inhibitors in Dogs and Humans
✍ Scribed by Haiyung Cheng; Steven C. Sutton; James D. Pipkin; Gaylen M. Zentner; J. Douglas Rogers; Jules I. Schwartz; Yale B. Mitchel; Kenneth Grasing; Michael S. Schwartz; Raju D. Amin; Lida Liu; David L. Ebel; Amy Coulter; Karen Engle; Gregory A. McClelland; Chung Y. Lui; Gerald S. Rork
- Book ID
- 110380696
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 844 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0724-8741
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We have used a cDNA clone for Chinese hamster 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase to isolate a genomic recombinant for human HMG-CoA reductase. The identity of the gene was confirmed by partial sequence analysis. Several unique fragments that will be useful for restriction frag
The apparent octanol-water partition coefficients (Po/w) and aqueous solubilities for four 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors [pravastatin, lovastatin (mevinolin), mevastatin (compactin), and simvastatin (synvinolin)] were compared. Pravastatin is highly hydrophilic