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Enhancement of 3-Hydroxy-3-methylglutaryl–Coenzyme A (HMG–CoA) Reductase Inhibitor Efficacy Through Administration of a Controlled-Porosity Osmotic Pump Dosage Form

✍ Scribed by Gregory A. McClelland; R. John Stubbs; Joseph A. Fix; Stefano A. Pogany; Gaylen M. Zentner


Book ID
110343452
Publisher
Springer US
Year
1991
Tongue
English
Weight
609 KB
Volume
08
Category
Article
ISSN
0724-8741

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Relative lipophilicities, solubilities,
✍ Abu T. M. Serajuddin; Sunanda A. Ranadive; Eileen M. Mahoney 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 532 KB

The apparent octanol-water partition coefficients (Po/w) and aqueous solubilities for four 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors [pravastatin, lovastatin (mevinolin), mevastatin (compactin), and simvastatin (synvinolin)] were compared. Pravastatin is highly hydrophilic