Relative lipophilicities, solubilities,
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Abu T. M. Serajuddin; Sunanda A. Ranadive; Eileen M. Mahoney
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Article
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1991
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John Wiley and Sons
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English
β 532 KB
The apparent octanol-water partition coefficients (Po/w) and aqueous solubilities for four 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors [pravastatin, lovastatin (mevinolin), mevastatin (compactin), and simvastatin (synvinolin)] were compared. Pravastatin is highly hydrophilic