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Hypocholesterolemic effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in the guinea pig: Atorvastatin versus simvastatin

✍ Scribed by Karin Conde; Graciela Pineda; Roger S Newton; Maria Luz Fernandez


Book ID
113994537
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
405 KB
Volume
58
Category
Article
ISSN
0006-2952

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Relative lipophilicities, solubilities,
✍ Abu T. M. Serajuddin; Sunanda A. Ranadive; Eileen M. Mahoney πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 532 KB

The apparent octanol-water partition coefficients (Po/w) and aqueous solubilities for four 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors [pravastatin, lovastatin (mevinolin), mevastatin (compactin), and simvastatin (synvinolin)] were compared. Pravastatin is highly hydrophilic