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The isolation, characterisation, and chromosomal assignment of the gene for human 3-hydroxy-3-methylglutaryl coenzyme A reductase, (HMG-CoA reductase)

✍ Scribed by S. E. Humphries; F. Tata; I. Henry; F. Barichard; M. Holm; C. Junien; R. Williamson

Publisher: Springer
Year: 1985
Tongue: English
Weight: 476 KB
Volume: 71
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00284585

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✦ Synopsis

We have used a cDNA clone for Chinese hamster 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase to isolate a genomic recombinant for human HMG-CoA reductase. The identity of the gene was confirmed by partial sequence analysis. Several unique fragments that will be useful for restriction fragment length polymorphism (RFLP) studies were identified. In situ hybridisation of a 2.6 kb unique fragment of the gene to human metaphase chromosomes localised the human HMGCoA reductase gene to human chromosome 5q12.

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