Evaluation of Dopamine D-2 Receptor Occupancy by Clozapine, Risperidone, and Haloperidol In Vivo in the Rodent and Nonhuman Primate Brain Using 18F-Fallypride
โ Scribed by Jogeshwar Mukherjee; Bradley T Christian; Tanjore K Narayanan; Bingzhi Shi; Joseph Mantil
- Book ID
- 114280806
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 412 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1470-634X
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๐ SIMILAR VOLUMES
[(18)F]Fallypride is a highly selective, high-affinity dopamine D-2 receptor ligand. The high affinity, K(D) = 30 pM, makes it a suitable candidate for visualizing both striatal and extrastriatal binding in the brain. In this work, dynamic PET studies of two macaque monkeys were acquired along with
We have investigated the ability of dopamine to compete with the binding of the high affinity dopamine D 2 receptor positron emission tomography (PET) radioligand, 18 F-fallypride. In vitro dissociation of 18 F-fallypride with dopamine in rat striatal homogenates exhibited a dissociation rate, k off