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Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride

✍ Scribed by Jae Yong Choi; Chul Hoon Kim; Tae Joo Jeon; Won Gil Cho; Jin Suk Lee; Soo Jin Lee; Tae Hyun Choi; Byoung Soo Kim; Chi Hoon Yi; Youngbeom Seo; Dae Ik Yi; Sang Jin Han; Minkyung Lee; Dong Goo Kim; Jong Doo Lee; Gwangil An; Young Hoon Ryu

Book ID
119192355
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
568 KB
Volume
70
Category
Article
ISSN
0969-8043

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[(18)F]Fallypride is a highly selective, high-affinity dopamine D-2 receptor ligand. The high affinity, K(D) = 30 pM, makes it a suitable candidate for visualizing both striatal and extrastriatal binding in the brain. In this work, dynamic PET studies of two macaque monkeys were acquired along with