Preliminary assessment of extrastriatal dopamine d-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, 18F-fallypride
โ Scribed by Jogeshwar Mukherjee; Zhi-Ying Yang; Terry Brown; Robert Lew; Miles Wernick; Xiaohu Ouyang; Nicholas Yasillo; Chin-Tu Chen; Robert Mintzer; Malcolm Cooper
- Book ID
- 117688379
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 610 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0969-8051
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[(18)F]Fallypride is a highly selective, high-affinity dopamine D-2 receptor ligand. The high affinity, K(D) = 30 pM, makes it a suitable candidate for visualizing both striatal and extrastriatal binding in the brain. In this work, dynamic PET studies of two macaque monkeys were acquired along with
We have investigated the ability of dopamine to compete with the binding of the high affinity dopamine D 2 receptor positron emission tomography (PET) radioligand, 18 F-fallypride. In vitro dissociation of 18 F-fallypride with dopamine in rat striatal homogenates exhibited a dissociation rate, k off