Evaluation of antithrombogenicity of ion-implanted silicone rubber

✍ Scribed by Masahiro Kusakabe; Yoshiaki Suzuki

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 406 KB
• Volume: 10
• Category: Article
• ISSN: 1042-7147
• DOI: 10.1002/(sici)1099-1581(199912)10:12<713::aid-pat932>3.0.co;2-j

✦ Synopsis

Ion implantations into silicone rods were performed at 150 keV with doses ranging from 1 Â 10 7 to 3 Â 10 17 ions/cm 2 . The antithrombogenicity was tested by the superior vena cava (SVC) indwelling method for two days in rats with 111 In-tropolone -platelets, and by the inferior vena cava (IVC) indwelling method. Results of the SVC indwelling method showed that platelet accumulation on ion -implanted specimens decreased. Macroscopic views of the ion-implanted IVC specimens in dogs revealed little thrombus formation. In particular, SVC indwelling method revealed that O 2 , K and Kr (1 Â 10 17 ions/cm 2 ) implantation was most effective in reducing platelet accumulation.