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Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy

✍ Scribed by F. Furukawa; M. Kashihara; S. Imamura; G. Ohshio; Y. Hamashima

Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
313 KB
Volume
278
Category
Article
ISSN
0340-3696

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✦ Synopsis

Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with double-stranded (ds) DNA, but not with singlestranded (ss) DNA or extractable nuclear antigens (ENA). We describe the unique pattern of antibody cross-reactivity with cardiolipin and dsDNA in sera of patients with lepromatous leprosy.

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