## Abstract Materials with the Clq binding properties of soluble immune complexes (IC) were found in sera from 11 of 51 consecutive (22%) children with juvenile rheumatoid arthritis (JRA) and in 17 of 20 adults with active seroβpositive rheumatoid arthritis (RA). IC appeared more frequently in chil
Evaluation of circulating immune complexes and antinuclear antibodies in Japanese patients with leprosy
β Scribed by F. Furukawa; K. Sekita; Y. Hamashima; M. Ozaki; S. Imamura
- Publisher
- Springer-Verlag
- Year
- 1983
- Tongue
- English
- Weight
- 318 KB
- Volume
- 275
- Category
- Article
- ISSN
- 0340-3696
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β¦ Synopsis
In 79 patients with leprosy a significant increase of anti-extractable nuclear antigen (ENA) antibodies and circulating immune complexes (CIC) was found. No correlation between CIC and anti-ENA antibodies was demonstrable. Since such a correlation is known from antinuclear antibodies and CIC in patients with systemic lupus erythematosus, it appears likely that anti-ENA antibodies do not play a causative role in CIC-mediated pathogenesis of leprosy.
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In the sera of patients with lepromatous leprosy anti-DNP antibodies were detected in order to determine the mode of polyclonal B-cell activation. Anti-DNP antibodies were found in 30% of the patients with active lepromatous leprosy and in 8% of those with inactive lepromatous leprosy. The level of
## Abstract Sera from 62 patients with osteogenic sarcoma and 12 with malignant giantβcell tumour were tested for the presence of immune complexes by the ^125^IβClq binding assay. Elevated serum Clq binding activity was found in 67.7% of the osteogenic sarcoma patients and in 75% of the giantβcell
## Abstract Fortyβone patients with progressive systemic sclerosis were studied for the presence of immune complexes by the fluidβ and solidβphase C1q binding, C1 activation, and the fluidβphase conglutinin assays. Complement activation and autoantibodies were also studied. Immune complexes were de