✦ LIBER ✦

Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives

✍ Scribed by Dr. D. A. Isenberg; Y. Shoenfeld; M. Walport; C. Mackworth-Young; C. Dudeney; A. Todd-Pokropek; S. Brill; A. Weinberger; J. Pinkas

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 757 KB
Volume: 28
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780280907

No coin nor oath required. For personal study only.

✦ Synopsis

Two common cross-reacting anti-DNA antibody idiotypes designated 1616 and 32/15, previously identified in the serum of patients who have systemic lupus erythematosus, were found in 24% and 7%, respectively, of 147 first-degree relatives. These findings imply that high-frequency germ-line genes exist among lupus relatives, as well as patients. These dominant or public anti-DNA antibody idiotypes are not likely to be pathogenic factors, but are probably a genetically associated phenomenon.

Evidence of a genetic basis for systemic lupus erythematosus (SLE) has been accumulated in a variety of studies. Population studies have indicated a particular predominance of black females (I), while

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