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Increased Antiretroviral Antibody Reactivity in Sera from a Defined Population of Patients with Systemic Lupus Erythematosus

✍ Scribed by Jonas Blomberg; Ola Nived; RüDiger Pipkorn; Anders Bengtsson; David Erlinge; Gunnar Sturfelt

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
1006 KB
Volume
37
Category
Article
ISSN
0004-3591

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✦ Synopsis

Objective. The implied role of retroviruses in the pathogenesis of murine systemic lupus erythematosus (SLE) led us to study antiretroviral antibodies in a population-based SLE cohort.

Methods. Immunoassays using whole virus and synthetic peptides were performed on sera from 72 patients with SLE and 88 control subjects.

Results. Reactions with whole baboon endogenous virus occurred more frequently in patients with SLE, and correlated with the presence of anti-RNP and anti8m. Some retroviral env and gag peptides, several of which were similar to U1 small nuclear RNP, reacted

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✍ Ferid Ben Fadhel; B. Guilbert; P. Matsiota; S. Avrameas; Y. Gorgi; K. Ayed 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 383 KB 👁 2 views

Sera obtained from fifty-five patients with active systemic lupus erythematosus (SLE) and from four patients with mixed connective tissue disease (MCTD) previously shown by immunofluorescence and by double immunodiffusion to possess antinuclear antibodies, were tested for the presence of natural ant