Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis
โ Scribed by Yunjin Jung; Hak-Hyun Kim; Heejung Kim; Hyesik Kong; Boim Choi; Youngwook Yang; Youngmi Kim
- Book ID
- 113591605
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 326 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0928-0987
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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti