A comparative study of the proliferative effect of 17 beta-estradiol and 17 alpha-estradiol on human estrogen-sensitive cell lines was performed. When using charcoal-dextran stripped human female sera-supplemented media the administration of t h e hormones, 17 alpha-estradiol at 3 x IO-"M, and 17 be
✦ LIBER ✦
Estrogenic and antiestrogenic activities of 16α- and 2-hydroxy metabolites of 17β-estradiol in MCF-7 and T47D human breast cancer cells
✍ Scribed by Mona Gupta; Andrew McDougal; Stephen Safe
- Book ID
- 117669105
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 256 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0960-0760
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We have previously reported that the proliferation of cloned MCF-7 and T47D human mammary tumor cells can be inhibited by increasing concentrations of charcoal-dextran stripped female human serum (CDFHS). The maximal proliferation rate was restored by the addition of 3 X 10(-11) M estradiol-17 beta