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Effects of interaction between estradiol-17β and progesterone on the proliferation of cloned breast tumor cells (MCF-7 and T47D)

✍ Scribed by Robert W. Schatz; Ana M. Soto; Carlos Sonnenschein

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
570 KB
Volume
124
Category
Article
ISSN
0021-9541

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✦ Synopsis

We have previously reported that the proliferation of cloned MCF-7 and T47D human mammary tumor cells can be inhibited by increasing concentrations of charcoal-dextran stripped female human serum (CDFHS). The maximal proliferation rate was restored by the addition of 3 X 10(-11) M estradiol-17 beta to the culture media. These observations suggest that the proliferation of T47D and MCF-7 cells is regulated by a blood-borne inhibitor whose effects are neutralized by estrogens. In the present report we explore the possibility that progesterone alters the estrogenic response. MCF-7 cells were grown in DME containing 2-40% CDFHS. Progesterone, at 3 X 10(-7) M to 3 X 10(-12) M, had no effect on the yield of MCF-7 or T47D cells that were cultured in the presence or absence of estradiol-17 beta.

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