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Estrogen inhibition of MPA-Induced mouse mammary tumor transplants

✍ Scribed by Edith Kordon; Claudia Lanari; Alfredo A. Molinolo; Patricia V. Elizalde; Eduardo H. Charreau; Christiane Dosne Pasqualini

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 667 KB
Volume: 49
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910490617

No coin nor oath required. For personal study only.

✦ Synopsis

Estrogen compounds were used to treat mice bearing syngeneic transplants of medroxyprogesterone acetate(MPA)-induced BALB/c mammary adenocarcinomas. Both MPA-dependent and MPA-independent tumor lines were used. These lines expressed estrogen (ER) and progesterone receptors (PR). We demonstrate that different doses of estradiol benzoate (EB) and 17-fi-estradiol (Ed inhibit tumor growth and induce tumor regression in both MPA-independent and -dependent tumors, even in the presence of MPA or progesterone (P). EB was unable to induce regression of (ER-) hormone-independent tumor lines. A few MPA-dependent tumors became resistant to the estrogenic treatment; in subsequent passages some of these tumors retained their MPA-responsiveness, although estrogen sensitivity was not recovered.

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