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Immunological studies on mouse mammary tumors. IV. Extraction and solubilization of transplantation antigen of mouse mammary tumor

✍ Scribed by Reiko Furuse Irie; Kusuya Nishioka; Takehiko Tachibana; Shoshichi Takeuchi

Publisher
John Wiley and Sons
Year
1969
Tongue
French
Weight
592 KB
Volume
4
Category
Article
ISSN
0020-7136

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✦ Synopsis

Antigens present in mouse mammary tumor M M 2 reacting with tumor-specific antibodies were extracted with 0.2 % deoxycholate. After the removal of deoxycholate by dialysis, most antigens were precipitated by centrifugation at 105,000 A g for 60 min. Hyperimmunization of C3HIHe mice with these antigens induced heightened resistance against MM2. Antibodies appeared in the serum after a booster injection of deoxycholate extract of tumor cells was given. Antigens were solubilized from deoxycholate extract with distilled water. Purified soluble antigen inhibited the neutralization activity of the tumor-specific antibody to M M 2 tumor. From these observations, it is concluded that transplaniation antigens of isografted mammary tumors in C3H/ He mice are present in deoxycholate extracts of M M 2 tumor.

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