Immunological studies on mouse mammary tumors. vi. further characterization of a mammary tumor antigen and its distribution in lymphatic cells of allogeneic mice

✍ Scribed by Shaoyuan Chang; Robert C. Nowinski; Kusuya Nishioka; Reiko F. Irie

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: French
• Weight: 533 KB
• Volume: 9
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910090220

✦ Synopsis

Abstract

A new lymphatic cell antigen of some laboratory mice which also occurs as a tumor‐specific antigen of ascitic mammary tumors of C3H mice was discovered. This antigen is not present in normal cells of C3H/He mice and is therefore capable of eliciting tumor‐specific immune reactions in C3H/He mice carrying that particular tumor, and also appears as an alloantigen in many of the 24 strains of laboratory mice examined, such as C57Bl/6, AKR, C58, 129, C57L, H‐2H, 101, RF, SJL/J and Swiss mice.

The name “MM antigen” seems appropriate for this cross‐reacting antigen detected on the surface of lymphatic cells. The antigen is regulated by a dominant gene independent of other known alloantigens. A designation of the locus MMa was given for this newly discovered antigen.

The similarity and difference between this antigen and TL antigen are discussed.