An equation was developed to be used with the method of residuals for the analysis of the linear one-compartment open model. This equation can provide information about the magnitude of the ratio of rate constants, without assuming that the terminal phase reflects solely either an elimination or an
Estimation of rate constants for absorption and elimination from blood concentration data
โ Scribed by John G. Wagner; Carl M. Metzler
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 166 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-3549
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Data are mean predicted k values. Conditions: (A) nine data sets, 10% random error; (6) six data sets, 20% random error; (C) nine data sets, limited Cand t,10% random error. The real value of k for conditions A-C is 0.5. Values in parentheses are coefficients of variation; ranges are ranges of predi
Two methods are presented for the quick estimation of kinetic parameters for a compartment with an exponential absorption rate and a first-order elimination rate. The first method is by direct computation from the observed levels of substance in the compartment at times t. 2t, and 3t, where t is arb