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Quick estimation of kinetic parameters for a compartment with exponential absorption rate and first-order elimination rate

โœ Scribed by C. D. Thron

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
288 KB
Volume
66
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

Two methods are presented for the quick estimation of kinetic parameters for a compartment with an exponential absorption rate and a first-order elimination rate. The first method is by direct computation from the observed levels of substance in the compartment at times t. 2t, and 3t, where t is arbitrary. The second method uses a numerical table to estimate the parameters from the observed peak level, the time of the peak level (or the time when the level rises to half on the peak level), and the time when the level has declined to half of its peak value. Some approximation equations also are given.

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Data are mean predicted k values. Conditions: (A) nine data sets, 10% random error; (6) six data sets, 20% random error; (C) nine data sets, limited Cand t,10% random error. The real value of k for conditions A-C is 0.5. Values in parentheses are coefficients of variation; ranges are ranges of predi