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Method of residuals: Estimation of absorption and elimination rate constants having comparable values

✍ Scribed by P. Macheras

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 387 KB
Volume: 8
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510080106

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✦ Synopsis

An equation was developed to be used with the method of residuals for the analysis of the linear one-compartment open model. This equation can provide information about the magnitude of the ratio of rate constants, without assuming that the terminal phase reflects solely either an elimination or an absorption process, as must be done for the graphical techniques. It also enhanced the analytical power of the method of residuals in that it gave better estimates of the absorption rate constant when the latter and the elimination rate constant have comparable magnitudes.

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Effect of using an incorrect elimination rate constant in application of the Wagner–Nelson method to theophylline data in cases of zero order absorption

✍ John G. Wagner 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 2 views

Some authors have used an elimination rate constant derived from one theophylline treatment (e.g. the elixir) to apply the Wagner-Nelson method to concentration-time data from another treatment (e.g. a sustained-release form). Since there is considerable intrasubject variation in the elimination rat