✦ LIBER ✦
Effect of using an incorrect elimination rate constant in application of the Wagner–Nelson method to theophylline data in cases of zero order absorption
✍ Scribed by John G. Wagner
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 363 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
✦ Synopsis
Some authors have used an elimination rate constant derived from one theophylline treatment (e.g. the elixir) to apply the Wagner-Nelson method to concentration-time data from another treatment (e.g. a sustained-release form). Since there is considerable intrasubject variation in the elimination rate constant of theophylline such a practice usually involves use of an incorrect rate constant. By means of theoretical treatment and simulations the effects of such a practice are shown and illustrated.