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Estimation of Impurity Profiles of Drugs and Related Materials. 12. Isolation and Identification of an Isomeric Impurity in Danazol

✍ Scribed by Gábor Balogh; Éva Csizér; György G. Ferenczy; Zsuzsanna Halmos; Bulcsu Herényi; Péter Horváth; Anna Laukó; Sándor Görög


Book ID
110346259
Publisher
Springer US
Year
1995
Tongue
English
Weight
609 KB
Volume
12
Category
Article
ISSN
0724-8741

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Estimation of impurity profiles of drugs
✍ Zs. Halmos; Cs. Szántay Jr.; J. Brlik; A. Csehi; K. Varga; P. Horváth; M. Kislak 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 330 KB

Besides several known impurities in cimetidine, two additional compounds at levels below 0.1% were detected by ion-pair reversed-phase high-performance liquid chromatography (HPLC). The impurities were isolated from crude cimetidine using normal-phase preparative HPLC. 1H and 13C NMR and mass spectr