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Isolation and structural identification of an impurity in fluconazole bulk drug substance

✍ Scribed by Vaijanath G. Dongre; Pradeep D. Ghugare; Pravin P. Karmuse; Satish R. Soudagar; Nalinakshya Panda; Ashok Kumar


Book ID
108189430
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
909 KB
Volume
45
Category
Article
ISSN
0731-7085

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Hydrochlorothiazide (6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7sulfonamide 1,1-dioxide) (HCTZ) 1 is a widely used diuretic and anti-hypertensive. Recently, the Pharmeuropa recognized a new impurity initially thought to be an HCTZ dimer 6, which consists of the active drug (HCTZ) linked via the