Hydrochlorothiazide (6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7sulfonamide 1,1-dioxide) (HCTZ) 1 is a widely used diuretic and anti-hypertensive. Recently, the Pharmeuropa recognized a new impurity initially thought to be an HCTZ dimer 6, which consists of the active drug (HCTZ) linked via the
✦ LIBER ✦
Isolation and identification of piperacillin amide as an impurity in piperacillin
✍ Scribed by Marshall M. Siegel; Richard Mills; Lane Gehrlein; William E. Gore; George Morton; Donna Cosulich; Jeffrey Medwid; P. Mirando; T. Chang
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 445 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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## Abstract A novel dimer, tetraethyl 2,2′,3,3′‐tetramethyl‐1,1′,2,2′‐tetrahydro‐4__H__,4′__H__‐2,2′‐bipyrrolyl‐5,5,5′,5′‐tetracarboxylate, has been isolated as an impurity (0.4% yield) from a Knorr reaction for the synthesis of ethyl 3,5‐dimethylpyrrole‐2‐carboxylate from 2,4‐pentanedione and diet