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Estimation of impurity profiles in drugs and related materials

✍ Scribed by Sándor Görög; Anna Laukó; Bulcsu Herényi

Book ID
103911002
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
537 KB
Volume
6
Category
Article
ISSN
0731-7085

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📜 SIMILAR VOLUMES

Estimation of impurity profiles of drugs
Estimation of impurity profiles of drugs and related materials Part 15. Identification of minor impurities in cimetidine
✍ Zs. Halmos; Cs. Szántay Jr.; J. Brlik; A. Csehi; K. Varga; P. Horváth; M. Kislak 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 330 KB

Besides several known impurities in cimetidine, two additional compounds at levels below 0.1% were detected by ion-pair reversed-phase high-performance liquid chromatography (HPLC). The impurities were isolated from crude cimetidine using normal-phase preparative HPLC. 1H and 13C NMR and mass spectr